NGS Target Enrichment Solutions
Achieve top-class efficiency and uniformity with NGS products from Twist Bioscience. WGS, WES panels, custom panels tailored to your needs, ready-made panels, long-read panels and much more.
Fully customised targeted panels from dozens to > 1,000,000 probes. DNA and RNA panels, long-read panels, customisation of ready-made panels. Fast manufacturing, NGS QC of every batch.
A 36.5 Mb exome that is regularly updated with new regions from the database. Higher uniformity, customisation options, suitable for both clinical and research use.
Library prep kit with Twist TrueAmp polymerase, specifically developed for low-input, FFPE and low-quality samples.
A specialised kit for library preparation from cell-free DNA. Optimised for the cfDNA fragmentation profile, with sensitive detection of low allele frequency variants.
A targeted MRD (minimal residual disease) solution with up to 500 personalised targets per patient. Residual disease monitoring and real-time relapse tracking.
Library prep kit for whole-genome sequencing without PCR amplification. No PCR duplicates, better coverage of GC-rich regions and a faithful representation of genomic distribution.
Twist Bioscience develops NGS Target Enrichment Solutions with a focus on coverage quality, speed of delivery and full panel flexibility. The probes are manufactured on a unique silicon platform, which gives them higher accuracy and uniformity than traditional probes based on column purification.
For clinical and research laboratories alike, Twist offers a complete portfolio: custom enrichment panels, Twist Exome, library prep kits for low-input and FFPE samples, liquid biopsy solutions (cfDNA, MRD) and PCR-free WGS, all with NGS QC validation of every batch.
Fully customised target enrichment panels from a few to more than 1,000,000 probes, for DNA, RNA and methylation workflows.
Twist Exome 2.0 and Comprehensive Exome with the best coverage uniformity on the market, plus a mitochondrial panel.
Targeted NGS panels for highly sensitive monitoring of minimal residual disease (MRD) through the detection of tumour-specific variants in circulating tumour DNA (ctDNA).
Traditional probe manufacturing takes place on columns: it is slow, costly and limited in volume. Twist moved this process onto a silicon chip. Hundreds of thousands of probes are produced in parallel on a single chip, with precise control over every position.
The result? Highly accurate dsDNA probes with NGS QC validation, large-scale manufacturing capability and full customisation from a few to more than a million probes in a single panel. For NGS this means better coverage uniformity, a higher on-target rate and lower sequencing capacity requirements for the same (or better) result.
High coverage uniformity thanks to precisely designed probes. Consistent coverage even in difficult regions, including GC-rich sequences.
Custom panels from a few to more than 1,000,000 probes. Coverage of individual regions can be adjusted to your requirements.
Our applications team will help you with the design. Custom panels are manufactured within 3 weeks, MRD Express panels even within 24 hours.
Twist supports projects ranging from small targeted panels to large-scale genomic studies, with the option to tailor products to the specific needs of research and clinical applications.
Twist probes achieve higher coverage uniformity across target regions. You can therefore reach the same target coverage (e.g. 100×) with less sequencing, which means a lower cost per sample and more samples in a single sequencing run.
Twist (green) vs. competitor (grey): a higher percentage of bases above the target depth at the same sequencing capacity.
Twist probes achieve higher coverage uniformity across target regions.
Our team of experienced application specialists provides expert support at every step of the process, from discussing your requirements and designing the optimal panel to placing the final order. We will help you choose the most suitable solution for your application and make sure the final panel meets your research and diagnostic goals.
We will help you choose the right product for your application.
